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Hydroxyethyl Starch 200/0.5 API
Hydroxyethyl starch (HES) 200/0.5 APIs, formed by acid-hydrolyzed and hydroxyethylizedhigh-branched chain amylopectin starch, is a medium MW and low molar substitutionratio HES. Its chemical formula is poly (O-2-hydroxyethyl) starch, and thecommon name is HES200/0.5 (penta starch).HES solution has quick effect and strong volume expansion properties; it can maintainfour hours` middle strength expansion; it can be cleared away from kidney;less accumulation in plasma and tissue, least effect on coagulation; it can improvemicrocirculation. HES 200/0.5 solution is the most frequently used plasma substitutein Europe, and is the preferred remedy in curing and defending hypovolemiaand shock.Pharmacology:Hydroxyethyl starch 200/0.5 can expand plasma volume, consequently improve the cardiacoutput and oxygen transport of low plasma volume and shock patient, reducethe pack of red cell and viscosity of blood plasma. Meanwhile, HES 200/0.5 hasits particular pharmacology in decreasing plasma leakage and dropsy of injured capillarytube, which will benefit the critically-ill patient who will be or wasin organ failurePharmacokinetics:The smaller the molar substitution ratio of HES is, the quicker it metabolize, buthigh C2/C6 ratio will slower the metaboly in body, accordingly decrease the effectof substitution. After the HES solution was given by intravenous infusion,the initial polymer can be separated into fractions of different molar masses. Theaverage molecular weight in the plasma will be declined to 70-80kd rapidly, andthen kept the value above the kidney threshold during therapy. The other largermolar masses will be metabolized by alpha-amylase, and then eliminated by renalexcretionToxicology:There is no one dead case among all the cured beastie, even under the maximum dosage.No teratogenicity was found in the teratogenicity research on rats and rabbits,no teratogenicity and embryotoxicity was inspected under the dosage of 20ml/kg,no indication of anti-procreate and immunity-toxicity in experiment on Guineapig. Meanwhile the experiments also proved that no mutagenicity, no carcinogenicity,no local toxicity of HES200/0.5Clinical usage:HES 200/0.5 solution is the mostly common used plasma substitute at present. It canimprove the cardiac output and oxygen transport of low plasma volume and shockpatient, reduce the pack of red cell and viscosity of blood plasma. Lots of clinicalexperiments have improved that it has beneficial effect in cardiac output,oxygen support, oxygen consume and organ function of low plasma volume and shockpatient
Hydroxyethyl starch (HES) 200/0.5 APIs, formed by acid-hydrolyzed and hydroxyethylized high-branched chain amylopectin starch, is a medium MW and low molar substitution ratio HES. Its chemical formula
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We are the leading supplier in China for food additives, special for energy drinkingredients and sweeteners. Pls visit our website: www.elongcom.com to get moreabout our company and products. If any o
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We are the leading supplier in China for food additives, special for energy drinkingredients and sweeteners. Pls visit our website: www.elongcom.com to get moreabout our company and products. If any o
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