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Cardiovascular Diseases Treatment Acadesine CAS: 2627-69-2 ()

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Cardiovascular Diseases Treatment Acadesine CAS: 2627-69-2

Cardiovascular Diseases Treatment AcadesineAcadesine CAS: 2627-69-2 Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE EINECS: 220-097-5 Molecular Formula: C9H14N4O5 Molecular Weight: 258.23 Storage Temp.: 20°cSolubility H2O: >10 Mg/MlMelting Point: 214-215 ° CBoiling Point: 726.3 ° C at 760 mmHgAssay: 98% Apperance: White or off-white powder. Product Categories: Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides;Protein Kinase;ARASINE;Cardiovascular APIs;PI3K/Akt/mTORUsage: Pharmaceutical intermediates. For the treatment of cardiovascular diseasesFunctions:AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

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