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Drospirenone
DrospirenoneAlias: 6b,7b:15b,16b-Dimethylen-3-oxo-17a-pregn-4-ene-21,17-carbolactone; DihydrospirorenoneCAS NO: 67392-87-4Molecular formula: C24H30O3Molecular weight: 366.49Assay:99%Purity :99% EINECS No.: 266-679-2Density: 1.26g/cm3Melting point: 196-200 ℃Boiling point: 552.2 ° C at 760 mmHgFlash point: 241.6 ° CSteam pressure: 3.07E-12mmHg at 25 ° Calpha: -180° (c=0.5, chloroform)InChI: InChI=1/C24H30O3/c1-22-6-3-12(25)9-17(22)13-10-14(13)20-16(22)4-7-23(2)21(20)15-11-18(15)24(23)8-5-19(26)27-24/h9,13-16,18,20-21H,3-8,10-11H2,1-2H3/t13-,14+,15-,16+,18+,20-,21+,22-,23+,24+/m1/s1Steam pressure: 3.07E-12mmHg at 25 ° CPacking: Foil bagUsage: Synthetic progestogen exhibiting antimineralocorticoid and antiandrogenic activity.Drospirenone (Drospirenone) and its analogues, is a kind of high efficient, low toxicity, no side effects of a new generation of steroidal contraceptives, first by France Schering company in 2000 developed the fourth generation of oral contraceptives, anti mineralocorticoid and anti androgenic effects, and wide market prospectDescription:Drospirenone (INN, USAN), also known as 1,2-dihydrospirorenone, is a synthetic hormone used in birth control pills and postmenopausal hormone replacement therapy pills.It is sold under the brand names Yasmin, Yasminelle, Yaz, Beyaz, Ocella, Zarah, Daylette and Angeliq, all of which arecombination products of drospirenone with an estrogen such as ethinylestradiol or estradiol.Drospirenone differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has potent antimineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and has also been shown to possess mild antiandrogen activity.
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