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Sex Enhancement Powder Dapoxetine hydrochloride CAS 129938-20-1 SteroidAlias: Priligy CAS No: 129938-20-1 MF: C21H23NO. HCl MW: 341.88 Purity: 98% Appearance: White powder, odorless, slightly sweet, soluble in water and alcohol. USES: Treat male premature ejaculation and erectile dysfunction.Quick Detail:Dapoxetine is the first compound developed specially for the treatment of premature ejaculation (PE) in men 18-64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the post synaptic cleft, and as a consequence promoting ejaculatory delay. As a member of selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.Description:Dapoxetine hydrochlorideEnglish Synonyms: DAPOXETIN;DAPOXETINE;(S-(+)-N,N-Dimethyl-a-[2-(naphthalenyloxy)ethyl]benzenemethanamine hydrochloride;Dapoxetine hydrochlorideCAS NO.: 119356-77-3Assay: 99%Molecular Formula: C21H23NO HCLMolecular Weight: 341.88Appearance: This product is light yellow powder, odorless, sweet, soluble in water, alcohol. Can be made into tablets, beverages, wine, capsules and other dosage formsUsage: Dapoxetine (dapoxetine) as a new fast SSRI, a short half life, a selective 5 - HT reuptake inhibitor (SSRI), for the treatment of premature ejaculation and erectile dysfunction. Dapoxetine is a selective 5 - HT reuptake inhibitor (SSRI), such drugs widely used to treat depression and related affective disordersApplications:Randomized, double blind, placebo-controlled trials have confirmed the efficacy of dapoxetine for the treatment of PE. Different dosage has different impacts on different type of PE. Dapoxetine 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 mg in men with lifelong PE, but there is no difference in men with acquired PE. Dapoxetine, given 1-3 hours before sexual episode, prolongs IELT, increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE. Since PE is associated with personal distress, interrelationship difficulty, dapoxetine provides help for men with PE to overcome this condition. Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when dapoxetine is used.[8] However, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction. Dapoxetine, on the other hand, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects.
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